Cheyenne was a big man, a former army scout who went west after the American Civil War and drifted from job to job, here a cowboy, there a lawman, and always a larger-than-life hero.
Tod Stiles and Buz Murdock continue their trek across North America, hopping from town to town and giving aid to anyone in need. Buz eventually stops traveling the road and Tod is joined by a new traveling companion, Lincoln Case.