Over the years, Megamind, has tried to conquer Metro City in every imaginable way. Each attempt has been a colossal failure thanks to the caped superhero known as "Metro Man." But now Megamind has actually defeated Metro Man in the throes of one of his botched evil plans. Suddenly, the fate of Metro City is threatened when a new villain arrives and chaos runs rampant, leaving everyone to wonder if the world's biggest "mind" can actually be the one...