When Luke Watson turns into a werewolf for the third time, he and his parents are moved to Scream Street, where they and other "unusual lifeforms" are trapped unless Luke and his friends can find six powerful relics hidden by the founding fathers before sinister landlord Sir Otto does.

With the sixth and final relic almost within his grasp, Luke learns something unexpected about the author who has been helping him in his quest to return with his terrified parents to his own world, presenting a dilemma that is not helped by a witch causing havoc in the neighborhood.