Quick-Stop potheads Jay and Silent Bob wreak vengeance on Hollywood, where Miramax is making a "Bluntman & Chronic" feature film inspired by the comic book version of the guys, but without their permission. En route from Jersey to Hollywood, the guys encounter sexy jewel thieves, a precocious orangutan, a dimwit wildlife marshal, and a nonstop parade of in-jokes and splendid celebrity cameos.

Pekar is a frustrated file clerk working at the local V.A. Hospital. He is also a comic book fan who befriends the young illustrator Robert Crumb and is soon inspired to create comic books based on his own life. Along his bumpy journey he meets, marries and falls in love with Joyce, an admiring comic book seller.