The Tribulation Force, a group of people who came to believe in God after being left behind on Earth after God's Rapture, ready themselves to fulfill Holy Scripture by setting up the assassination of the Antichrist.

An evil world leader proclaims himself the Antichrist, drawing up plans to mark all human beings, but the members of the Tribulation Force are determined to stop him.

Pilot Rayford Steele and reporter Buck Williams begin searching for their loved ones after the global earthquake in the twenty-first month of the Tribulation.

The second half of the seven-year tribulation era begins as Rayford, Buck, Chloe, and the other members of the Tribulation Force reveal who killed Nicolae as the time of God's judgment approaches.