When lowly space pirate Tyler gets his hands on the key to the chamber of immortality, he becomes a powerful psychopath prepared to destroy anything and anyone in his path. After he ravages the peaceful planet Eden, F.A.K.K. 2 rises from the ashes of her fallen planet to hunt Tyler, rescue her kidnapped sister and reclaim the key to immortality.

Blends fictional characters and situations with the lives of real people: obsessive orchid hunter John Laroche, "New Yorker" journalist Susan Orlean, Hollywood screenwriter Charlie Kaufman and his twin brother Donald. As Charlie struggles to adapt a best-selling book, he writes himself into the movie plot.

Trapped in their New York brownstone's panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg and her daughter Sarah play a deadly game of cat-and-mouse with three intruders during a brutal home invasion. But the room itself is the focal point because what the intruders really want is inside it.