With Nonnatus House scheduled for demolition, Jenny, Chummy, and Sister Julienne search for a new location nearby, while Jenny₂s relationship with Alec continues to blossom. But an outbreak of polio affects the nurses and nuns more than they could have imagined.

Now nearing the 1960s, the community enters a new time of social change, while stories of birth, life and death continue to touch your heart. Will live-wire Nurse Trixie marry her young curate? What new project calls for a heart as big as Chummy's? How will Sister Evangelina react to two new nurses? And why does Sister Julienne appear so unsettled by a mystery benefactor?