The Collector has sent Man-Wolf and Drax the Destroyer to capture super heroes and villains for his collection. Iron Man, Reptil, Wolverine, Falcon, and Silver Surfer must find a way to free the captives.
When a Fractal turns a paleontologist into a dinosaur, Speedball joins the squaddies in the Savage Land to stop him from commanding the dinosaurs to take over the world.
When one of the shattered Infinity Sword's fractals mutates a jellyfish into a slime monster, Reptil, Hulk, Iron Man, Silver Surfer, Falcon, Thor, and Wolverine must find a way to stop it.
Doom and M.O.D.O.K. have devised a plan to use the brain-beam to transfer Hulk's low IQ to the rest of the Super Hero Squad. Will their plan work? Or will Hulk's other abilities transfer instead?